Augmentation of Morphine-Induced Sensitization but Reduction in Morphine Tolerance and Reward in Delta-Opioid Receptor Knockout Mice
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چکیده
منابع مشابه
Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice
Gene targeting was used to delete exon 2 of mouse DOR-1, which encodes the delta opioid receptor. Essentially all 3H-[D-Pen2,D-Pen5]enkephalin (3H-DPDPE) and 3H-[D-Ala2,D-Glu4]deltorphin (3H-deltorphin-2) binding is absent from mutant mice, demonstrating that DOR-1 encodes both delta1 and delta2 receptor subtypes. Homozygous mutant mice display markedly reduced spinal delta analgesia, but pepti...
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The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. Daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance obtained was decreased by pretreatment of animals with single or repeated doses of compe...
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In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...
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In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...
متن کاملAnesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice.
BACKGROUND The involvement of the mu-opioid receptor (muOR) system in the control of breathing, anesthetic potency, and morphine- and anesthesia-induced respiratory depression was investigated in mice lacking the muOR. METHODS Experiments were performed in mice lacking exon 2 of the muOR gene (muOR-/-) and their wild-type littermates (muOR+/+). The influence of saline, morphine, naloxone, and...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2008
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2008.128